| NAME Stefan R. Bornstein M.D. |
TITLE/GRADE Heisenberg-Professor of Deutsche Forschungs Gemeinschaft | BIRTHDATE & PLACE November 11, 1961 |
CITIZENSHIP Germany |
| INSTITUTE/DIVISION/LABORATORY National Institute of Child Health, Pediatric Endocrinology Section |
OFFICE (Bldg./Room No.) Bldg.10, Rm 10N262 |
LABORATORY 10N262, 10N244 |
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| EDUCATION AND TRAINING | |||
| Years 1982-1987 |
Institution ULM University |
Degree
M.D |
Discipline Medicine |
| CHRONOLOGY OF EMPLOYMENT | |||
| 1994-1997
1997-present |
Assistant Professor of Internal Medicine
-Heisenberg Professorship of German Research Foundation |
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| RESEARCH INTERESTS AND ACCOMPLISHMENTS Our group studies the interaction of the endocrine system with the nervous system and the immune system. We were among the first to describe the close interaction of the sympathoadrenal system and the Hypothalamic-Pituitary-Adrenal axis at the level of the adrenal gland. We could demonstrate a direct effect of Corticotropin Releasing hormone on the adrenal in the absence of pituitary ACTH. The two parts of the adrenal medulla and cortex are interwoven to an astonishing degree with cortical cells located within the medulla and cromaffin cells found within the cortex; thus, medullary and cortical cells work in parallel and communicate extensively, allowing for instant paracrine effects and potentiation of endocrine actions. Cellular proximity and functional coordination between the two systems may explain several of the discrepancies between cortisol secretion and its main regulatory hormone, adrenocorticotropin (ACTH). Second, we have demonstrated that immune cells reside within the adrenal cortex, interact with both adrenocortical and medullary cells and, thus, regulate adrenal hormone secretion. Cytokines like IL-1, IL-6 and TNF , in addition to regulating HPA axis function in a nonendocrine manner, are expressed within the adrenal gland tissue and interact with its cells in situ. The notion of a potent endocrine and paracrine interaction between the immune and endocrine systems at the level of the adrenal gland is supported by the number of reports showing strong interdependence of cytokine and adrenal hormone levels in clinical states, such as sepsis, exercise and inflammation Recently, we have established an important metabolic link to the adrenal mediated by a direct action of leptin, the newly discovered adipostatic hormone on steroidogenesis. |
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| IMPORTANT AND RECENT PUBLICATIONS
Total Number of Publications: 68 (1) Bornstein SR; Ehrhart-Bornstein M; Scherbaum WA; Pfeiffer EF; Holst JJ: Effects of splanchnic nerve stimulation on the adrenal cortex may be mediated by chromaffin cells in a paracrine manner. Endocrinology 1990 Aug;127(2):900-6 (2) Bornstein SR; Ehrhart-Bornstein M: Ultrastructural evidence for a paracrine regulation of the rat adrenal cortex mediated by the local release of catecholamines from chromaffin cells Endocrinology 1992 Dec;131(6):3126-8 (3) Bornstein SR; Gonzales-Hernandez JA; Ehrhart-Bornstein M, et al. 1994 Intimate contact of cromaffin and cortical cells within the human adrenal gland forms the cellular basis for important intraadrenal interactions. J Clin Endocrinol Metab. 78: 225-232 (4) Gonzalez-Hernandez JA; Ehrhart-Bornstein M; Spath-Schwalbe E; Scherbaum WA; Bornstein SR: Human adrenal cells express tumor necrosis factor-alpha messenger ribonucleic acid: evidence for paracrine control of adrenal function J Clin Endocrinol Metab 1996 Feb;81(2):807-13. (5) Bornstein SR; Breidert M; Ehrhart-Bornstein M; Kloos B; Scherbaum WA: Plasma catecholamines in patients with Addison's disease. Clin Endocrinol (Oxf) 1995 Feb;42(2):215-8. (6). Spath-Schwalbe E; Born J; Schrezenmeier H; Bornstein SR; Stromeyer P; Drechsler S; Fehm HL: Porzsolt F Interleukin-6 stimulates the hypothalamus-pituitary-adrenocortical axis in man. J Clin Endocrinol Metab 1994 Oct;79:1212-4. . (7) Bornstein SR; Ehrhart-Bornstein M; Guse-Behling H; Scherbaum WA: Structure and dynamics of adrenal mitochondria following stimulation with corticotropin releasing hormone. Anat Rec 1992 Oct;234(2):255-62. (8) Bornstein SR; Ehrhart M; Scherbaum WA; Pfeiffer EF: Adrenocortical atrophy of hypophysectomized rats can be reduced by corticotropin-releasing hormone (CRH). Cell Tissue Res 1990 Apr;260(1):161-6. (9) Bornstein, S.R. et al. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Diabetes 1997; 46, 1-4. (10) Ehrhart-Bornstein M, Hinson JP, Bornstein SR, Scherbaum WA, Vinson GP. Intra-adrenal regulation of adrenocortical function. Endocr. Rev. 19:1998. (11) Willenberg H, Stratakis CA, et al. Aberrant interleukin-1 receptor in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. N engl J Med, 1998 in press. (12) Bornstein SR, Webster EL, Torpy DJ, Richman SJ et al. Chronic effects of a nonpeptide corticotropin-releasing hormone type-1-receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation. Endocrinology 139:1546-1555:1998. (13) Bornstein SR. Is leptin a stress-related peptide? Nat Med. 3:937:1997. |
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AWARDS, HONORS, EDITORSHIPS, and COMMITTEES
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